Biomate 723
2,2-Dibromo-3-Nitrilopropionamide
CAS: 10222-01-2
Molecular Formula: C3H2Br2N2O
Biomate 723 - Names and Identifiers
Biomate 723 - Physico-chemical Properties
| Molecular Formula | C3H2Br2N2O |
| Molar Mass | 241.87 |
| Density | 2.3846 (rough estimate) |
| Melting Point | 122-125°C(lit.) |
| Boling Point | 123-126 °C |
| Flash Point | 87.8°C |
| Water Solubility | Slightly soluble in water |
| Vapor Presure | 0.107mmHg at 25°C |
| Appearance | White crystal |
| Color | White to Light yellow to Light orange |
| pKa | 11.72±0.50(Predicted) |
| Storage Condition | Inert atmosphere,2-8°C |
| Stability | Stable, but may be moisture sensitive. Incompatible with strong oxidizing agents. |
| Refractive Index | 1.6220 (estimate) |
| MDL | MFCD00129791 |
| Physical and Chemical Properties | White crystals. Melting point of 125 ° C, soluble in general organic solvents (such as acetone, benzene, dimethylformamide, ethanol, polyethylene glycol, etc.), slightly soluble in water (25 ° C, 1.5g water dissolved in g). Its aqueous solution is stable under acidic conditions, and it is easy to hydrolyze under alkaline conditions. The dissolution rate can be greatly accelerated by increasing the pH value, heating, and irradiation with ultraviolet light or fluorescence. It is easy to be debrominated by a reducing agent, such as hydrogen sulfide, and becomes a non-toxic cyanoacetic acid amine, which greatly reduces the sterilization rate. When the pH value was changed from 6.7 to 9.7, the half-life was also changed from 37.0h to 0.11h. |
| Use | Is a broad-spectrum and efficient industrial bactericide, used to prevent bacteria and algae in paper, industrial circulating cooling water, metal processing lubricants, Pulp, wood, paint and plywood in the growth and reproduction, at the same time can do slime control agent, widely used in paper mill pulp and circulating cooling water system. As a broad-spectrum and efficient biocide, it can quickly penetrate the cell membrane of microorganisms and act on certain protein groups to stop the normal redox of cells, thus causing cell death. At the same time, its branches can also selectively bromination or oxidation of specific enzyme metabolites of microorganisms, eventually leading to microbial death. This product has good peeling performance, no foam when used, liquid products and water can be freely miscible, low toxicity. |
Biomate 723 - Risk and Safety
| Risk Codes | R34 - Causes burns R43 - May cause sensitization by skin contact R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37 - Wear suitable protective clothing and gloves. |
| UN IDs | UN 1759 8/PG 3 |
| WGK Germany | 3 |
| RTECS | AB5956000 |
| HS Code | 29209090 |
| Hazard Class | 6.1(b) |
| Packing Group | III |
| Toxicity | LD50 oral in mammal (species unspecified): 118mg/kg |
Biomate 723 - Nature
Open Data Verified Data
white crystals. Slightly soluble in water [25 ℃,1.5g/ILOG (water)], its aqueous solution is more stable under acidic conditions, easy to hydrolyze under alkaline conditions, soluble in acetone, benzene, dimethylformamide, ethanol, polyethylene glycol and other organic solvents. Increasing the pH value or heating, UV irradiation, can accelerate its decomposition. Easy to be reducing agent, in case of hydrogen sulfide is decomposed into non-toxic cyanoethyl Amine, will affect its sterilization efficiency.
Last Update：2025-06-10 22:55:16
Biomate 723 - Preparation Method
Open Data Verified Data
using chloroacetic acid as a raw material, chloroacetic acid was neutralized with sodium carbonate or sodium hydroxide to obtain sodium chloroacetate, and then reacted with sodium cyanide in a butanol solution to obtain sodium cyanacetate. After acidification with concentrated sulfuric acid, esterification with methanol or butanol is carried out, and the obtained methyl cyanoacetate is hydrolyzed into cyanoacetamide by amine and then brominated.
Last Update：2025-06-10 22:55:16
Biomate 723 - Application
Open Data Verified Data
used as a bactericidal algicide, can prevent bacteria and algae in the paper industry water, industrial cooling water, air conditioning water, metal processing lubricating oil, water emulsion, Pulp, wood, plywood, growth in coatings and fibers. DBNPA can not only control the micro-organisms, but also can strip off the original plug of the slime, restore the evaporation efficiency of the cooling tower. It has the advantages of low dosage, high efficiency and fast sterilization, and has a good synergistic effect with many kinds of fungicides.
Last Update：2025-08-19 16:24:40
Biomate 723 - Safety
Open Data Verified Data
female guinea pig LD50:118mg/kg. Has a stimulating effect on the skin, can cause skin and eye damage, the staff should be protected. Inhalation of smoke or vapor should be avoided, and the working environment should be well ventilated.
Last Update：2022-01-01 09:29:19
Biomate 723 - Reference Information
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| use | this product is a broad-spectrum and efficient biocide. Its molecules can quickly penetrate the cell membrane of microorganisms and act on certain protein groups to terminate the normal oxidation-reduction of cells, thereby causing cell death. In addition, its molecules can selectively brominate or oxidize special enzyme metabolites in microorganisms, eventually leading to the death of microorganisms. It is mainly used as a bactericidal algicide to prevent bacteria and algae from growing in paper industry water, industrial cooling water, air conditioning water, lubricating oil for metal processing, water emulsion, pulp, wood, plywood and coatings, and fibers. Using 15ppm 20% DBNPA can achieve good results. It can not only control the microorganisms, but also peel off the slime clumps originally filled with fillers and restore the evaporation efficiency of the cooling tower. The toxicity of the product to animals is moderate, and the LD50 of female guinea pigs is 118mg/kg. is a broad-spectrum and efficient industrial fungicide, used to prevent bacteria and algae in paper, industrial circulating cooling water, metal processing lubricants, pulp, wood, paint and plywood in the growth and reproduction, at the same time can be used as slime control agent, widely used in paper mill pulp and circulating cooling water system. As a broad-spectrum and high-efficiency biocide, it can quickly penetrate the cell membrane of microorganisms and act on a certain protein group to stop the normal redox of the cells, thereby causing thinness. It is a broad-spectrum and high-efficiency industrial fungicide. Prevent the growth and reproduction of bacteria and algae in papermaking, industrial circulating cooling water, metal processing lubricants, pulp, wood, paint and plywood, and can be used as a slime control agent at the same time, widely used in paper mill pulp and circulating cooling water systems. As a broad-spectrum and efficient biocide, it can quickly penetrate the cell membrane of microorganisms and act on certain protein groups to stop the normal redox of cells and cause cell death. At the same time, its branches can selectively brominate or oxidize special enzyme metabolites of microorganisms, eventually leading to the death of microorganisms. This product has good peeling performance, no foam when used, liquid products and water can be arbitrarily miscible, low toxicity. It is used as a pharmaceutical intermediate, bactericidal algicide, industrial sewage treatment agent, etc. This product is a broad-spectrum and efficient biocide. |
| production method | there are many methods for preparing dibromoazepam. Chloroacetic acid, cyanoacetic acid, dialkylaminoacrolein, aminoacetal glycol and methyl cyanoacetate can be used as starting materials to prepare cyanoacetamide first, and then perform bromination reaction to obtain the product. When synthesizing with cyanoacetic acid as the starting material, first neutralize chloroacetic acid with sodium carbonate or sodium hydroxide to prepare sodium chloroacetate; then react with sodium cyanide in butanol solution to generate sodium cyanoacetate, And then acidify with hydrochloric acid. The obtained cyanoacetic acid is esterified with methanol or butanol to form methyl cyanoacetate or butyl ester, and then ammonolysis to obtain cyanoacetamide. Finally, bromination gives 2, 2-dibromo-3-azacronium amide. |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 15:16:46
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